Acute stimulation in the external segment of the globus pallidus improves parkinsonian motor signs
Identifieur interne : 003E28 ( Main/Exploration ); précédent : 003E27; suivant : 003E29Acute stimulation in the external segment of the globus pallidus improves parkinsonian motor signs
Auteurs : Jerrold L. Vitek [États-Unis] ; Takao Hashimoto [Japon] ; John Peoples [États-Unis] ; Mahlon R. Delong [États-Unis] ; Roy A. E. Bakay [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-08.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Brain Mapping, Dose-Response Relationship, Radiation, Dyskinesias (etiology), Dyskinesias (therapy), Electric Stimulation (methods), Electric Stimulation Therapy, Female, Functional Laterality, Globus Pallidus (anatomy & histology), Globus Pallidus (physiology), Globus Pallidus (radiation effects), Humans, Male, Motor Activity (radiation effects), Nervous system diseases, Neural Networks (Computer), Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Reaction Time (radiation effects), Retrospective Studies, Sign, deep brain stimulation, globus pallidus, parkinsonism.
- MESH :
- anatomy & histology : Globus Pallidus.
- complications : Parkinson Disease.
- etiology : Dyskinesias.
- methods : Electric Stimulation.
- physiology : Globus Pallidus.
- radiation effects : Globus Pallidus, Motor Activity, Reaction Time.
- therapy : Dyskinesias, Parkinson Disease.
- Brain Mapping, Dose-Response Relationship, Radiation, Electric Stimulation Therapy, Female, Functional Laterality, Humans, Male, Neural Networks (Computer), Retrospective Studies.
Abstract
High frequency (>100Hz) electrical stimulation in both the external (GPe) and internal (GPi) segments of the globus pallidus was effective in improving parkinsonian motor signs. Improvement generally occurred at short latency (<5–10 seconds) in both GPe and GPi but was often (50% of the time) delayed in GPi. Dyskinetic movements were observed during stimulation within GPe and GPi but were more frequent in GPe (20% vs. 9%). These findings suggest that electrical stimulation in both GPe and GPi may ameliorate parkinsonian motor signs. The mechanisms responsible for these observations, however, may differ. The tendency for delayed responses with GPi stimulation suggests a more complex spatial–temporal profile of stimulation on the electrical activity of GPi neurons and/or its effect on network activity in pallido‐thalamo‐cortical circuitry. The rarity of delayed effects with GPe stimulation suggests a more direct role of synaptic inhibition or normalization of neuronal activity of GPi either directly by means of activation of striatopallidal fibers passing through GPe (direct pathway), by means of activation of GPe→GPi or GPe→subthalamic nucleus projections (indirect pathway) or indirectly by means of the tonic activation of adjacent fiber pathways. These data provide a rationale for the exploration of electrical stimulation in GPe in patients with medically intractable Parkinson's disease and provide a basis on which to develop further investigations into the use of chronic electrical stimulation for the treatment of Parkinson's disease and other movement disorders. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20137
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-08">2004-08</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="907">907</biblScope><biblScope unit="page" to="915">915</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">65E2863AB48718F30C08FB2497454040FF5940A6</idno><idno type="DOI">10.1002/mds.20137</idno><idno type="ArticleID">MDS20137</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Mapping</term><term>Dose-Response Relationship, Radiation</term><term>Dyskinesias (etiology)</term><term>Dyskinesias (therapy)</term><term>Electric Stimulation (methods)</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Functional Laterality</term><term>Globus Pallidus (anatomy & histology)</term><term>Globus Pallidus (physiology)</term><term>Globus Pallidus (radiation effects)</term><term>Humans</term><term>Male</term><term>Motor Activity (radiation effects)</term><term>Nervous system diseases</term><term>Neural Networks (Computer)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Reaction Time (radiation effects)</term><term>Retrospective Studies</term><term>Sign</term><term>deep brain stimulation</term><term>globus pallidus</term><term>parkinsonism</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Globus Pallidus</term><term>Motor Activity</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term><term>Dose-Response Relationship, Radiation</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Neural Networks (Computer)</term><term>Retrospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Signe</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High frequency (>100Hz) electrical stimulation in both the external (GPe) and internal (GPi) segments of the globus pallidus was effective in improving parkinsonian motor signs. Improvement generally occurred at short latency (<5–10 seconds) in both GPe and GPi but was often (50% of the time) delayed in GPi. Dyskinetic movements were observed during stimulation within GPe and GPi but were more frequent in GPe (20% vs. 9%). These findings suggest that electrical stimulation in both GPe and GPi may ameliorate parkinsonian motor signs. The mechanisms responsible for these observations, however, may differ. The tendency for delayed responses with GPi stimulation suggests a more complex spatial–temporal profile of stimulation on the electrical activity of GPi neurons and/or its effect on network activity in pallido‐thalamo‐cortical circuitry. The rarity of delayed effects with GPe stimulation suggests a more direct role of synaptic inhibition or normalization of neuronal activity of GPi either directly by means of activation of striatopallidal fibers passing through GPe (direct pathway), by means of activation of GPe→GPi or GPe→subthalamic nucleus projections (indirect pathway) or indirectly by means of the tonic activation of adjacent fiber pathways. These data provide a rationale for the exploration of electrical stimulation in GPe in patients with medically intractable Parkinson's disease and provide a basis on which to develop further investigations into the use of chronic electrical stimulation for the treatment of Parkinson's disease and other movement disorders. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Vitek, Jerrold L" sort="Vitek, Jerrold L" uniqKey="Vitek J" first="Jerrold L." last="Vitek">Jerrold L. Vitek</name></region><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><name sortKey="Peoples, John" sort="Peoples, John" uniqKey="Peoples J" first="John" last="Peoples">John Peoples</name></country><country name="Japon"><noRegion><name sortKey="Hashimoto, Takao" sort="Hashimoto, Takao" uniqKey="Hashimoto T" first="Takao" last="Hashimoto">Takao Hashimoto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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